Article

Neuromodulatory Signaling in Chronic Pain Patients: A Systematic Review

2025-07-29

Abstract excerpt

Chronic pain is a complex and persistent condition involving sustained nociceptive input, maladaptive neuroplastic changes, and neuroimmune interactions. Central to its pathophysiology is the dysregulation of neuromodulatory signaling pathways, including neurotransmitters (e.g., dopamine, serotonin, norepinephrine), neuropeptides (e.g., substance P, CGRP), and neurotrophic factors (e.g., BDNF), which modulate both...

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Literature Corpus work: ffe2fd97-3642-507e-92bb-8249ec053e7f
DOI: 10.20944/preprints202507.2351.v1

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