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Article

Prednisolone induces osteoporosis-like phenotypes via focal adhesion signaling pathway in zebrafish larvae

15 Jul 2018

Abstract excerpt

ABSTRACT Patients taking glucocorticoid or glucocorticoid-like drugs for an extended period of time may develop osteoporosis, termed glucocorticoid-induced osteoporosis (GIOP). GIOP is the most common form of secondary osteoporosis, but the mechanism underlying its development is unclear. In the present study, we used prednisolone to treat zebrafish larvae to investigate GIOP. Our RNA deep-sequencing (RNA-seq)...

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PMID: 30012552
DOI: 10.1242/bio.029405

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