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Article

Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells.

The Journal of biological chemistry - 13 Mar 2020

Okubo Toru, Hayashi Ryuhei, Shibata Shun, Kudo Yuji, Ishikawa Yuki, Inoue Saki, Kobayashi Yuki, Honda Ai, Honma Yoichi, Kawasaki Satoshi, Nishida Kohji

Abstract excerpt

PITX2 (Paired-like homeodomain transcription factor 2) plays important roles in asymmetric development of the internal organs and symmetric development of eye tissues. During eye development, cranial neural crest cells migrate from the neural tube and form the periocular mesenchyme (POM). POM cells differentiate into several ocular cell types, such as corneal endothelial cells, keratocytes, and some ocular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32034090
DOI: 10.1074/jbc.RA119.010713
PMCID: PMC7076207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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