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Generating minicorneal organoids from human induced pluripotent stem cells

1 Jan 2017

Abstract excerpt

Corneal epithelial stem cells residing within the annular limbal crypts regulate adult tissue homeostasis. Autologous limbal grafts and tissue engineered corneal epithelial cell sheets have been widely used in the treatment of various ocular surface defects. In case of bilateral limbal defects, pluripotent stem cell (PSC) derived corneal epithelial cells are now being explored as an alternative to allogeneic...

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PMID: 28559289
DOI: 10.1242/dev.143040

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