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Pan-cancer analyses of human nuclear receptors reveal transcriptome diversity and prognostic value across cancer types

5 Feb 2020

Abstract excerpt

The human nuclear receptor (NR) superfamily comprises 48 ligand-dependent transcription factors that play regulatory roles in physiology and pathophysiology. In cancer, NRs have long served as predictors of disease stratification, treatment response, and clinical outcome. The Cancer Genome Atlas (TCGA) Pan-Cancer project provides a wealth of genetic data for a large number of human cancer types. Here, we examined...

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PMID: 32024906
DOI: 10.1038/s41598-020-58842-6

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