Article
Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis.
The British journal of ophthalmology - 1 Oct 2020
Thornton Sophie, Coupland Sarah E, Heimann Heinrich, Hussain Rumana, Groenewald Carl, Kacperek Andrzej, Damato Bertil, Taktak Azzam, Eleuteri Antonio, Kalirai Helen
Abstract excerpt
BACKGROUND/AIMS: Proton beam radiotherapy and plaque brachytherapy are commonly applied in primary uveal melanoma (UM); however, their effect on chromosome 3 classification of UM by microsatellite analysis (MSA) for prognostication purposes is unknown, where the tumour is sampled post-irradiation. This study examined the prognostic accuracy of genotyping UM biopsied before or after administration of radiotherapy,...
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