Article
Genomic microarray analysis on formalin-fixed paraffin-embedded material for uveal melanoma prognostication.
Cancer genetics - 1 Jan 2000
Minca Eugen C, Tubbs Raymond R, Portier Bryce P, Wang Zhen, Lanigan Christopher, Aronow Mary E, Triozzi Pierre L, Singh Arun, Cook James R, Saunthararajah Yogen, Plesec Thomas P, Schoenfield Lynn, Cawich Victoria, Sulpizio Scott, Schultz Roger A
Abstract excerpt
Cytogenetic alterations are strong outcome prognosticators in uveal melanoma (UVM). Monosomy 3 (-3) and MYC amplification at 8q24 are commonly tested by fluorescence in situ hybridization (FISH). Alternatively, microarray analysis provides whole genome data, detecting partial chromosome loss, loss of heterozygosity (LOH), or abnormalities unrepresented by FISH probes. Nonfixed frozen tissue is conventionally used...
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