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Article

Disassembly of the ring-type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation.

Protein science : a publication of the Protein Society - 1 May 2020

Himiyama Tomoki, Nakamura Tsutomu

Abstract excerpt

The quaternary structure of peroxiredoxin from Aeropyrum pernix K1 (ApPrx) is a decamer, in which five homodimers are assembled in a pentagonal ring through hydrophobic interactions. In this study, we determined the amino acid (AA) residues of ApPrx crucial for forming the decamer using AA mutations. The ApPrx0Cys mutant, wherein all cysteine residues were mutated to serine, was prepared as a model protein to...

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PMID: 32022337
DOI: 10.1002/pro.3837
PMCID: PMC7184774

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