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Article

Transient abnormal myelopoiesis in a phenotypically normal newborn with polyclonal trisomy 21.

International journal of hematology - 1 Jun 2014

Corazza Francesco, Astolfi Annalisa, Libri Virginia, Franzoni Monica, Serravalle Salvatore, Alessandroni Rosina, Melchionda Fraia, Pession Andrea

Abstract excerpt

We report a rare case of transient abnormal myelopoiesis (TAM) in a phenotypically normal neonate. The presence of a palpable hepatomegaly prompted in-depth laboratory tests, which revealed the presence of severe hyperleukocytosis, with blast cells present in a peripheral blood smear. Although no signs of Down syndrome were present, we suspected TAM. Further analysis identified a mutation in GATA1 along with the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24771229
DOI: 10.1007/s12185-014-1584-0

Genes

GATA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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