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Article

BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data.

Genome biology and evolution - 1 Feb 2020

Siewert Katherine M, Voight Benjamin F

Abstract excerpt

Long-term balancing selection results in a build-up of alleles at similar frequencies and a deficit of substitutions when compared with an outgroup at a locus. The previously published β(1) statistics detect balancing selection using only polymorphism data. We now propose the β(2) statistic which detects balancing selection using both polymorphism and substitution data. In addition, we derive the variance of all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32011695
DOI: 10.1093/gbe/evaa013
PMCID: PMC7058154

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