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Article

ALDOA coordinates PDE3A through the β-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations.

Biochemical and biophysical research communications - 12 Feb 2024

Yeh Chia-Ying, Cai Huei Yu, Kuo Han-His, Lin You-Yu, He Zhao-Jing, Cheng Hsiao-Chen, Yang Chih-Jen, Huang Chi-Ying F, Chang Yu-Chan

Abstract excerpt

Lung cancer has a high incidence rate and requires more effective treatment strategies and drug options for clinical patients. EGFR is a common genetic alteration event in lung cancer that affects patient survival and drug strategy. Our study discovered aberrant aldolase A (ALDOA) expression and dysfunction in lung cancer patients with EGFR mutations. In addition to investigating relevant metabolic processes like...

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Identifiers

PMID: 38244313
DOI: 10.1016/j.bbrc.2024.149489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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