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Gestational homocysteine exposure induces preeclampsia-like phenotypes and alters fetal neurodevelopmental gene expression via impaired decidualization.

Life sciences - 1 Oct 2026

Li Xuexiang, Wang Ningjing, Cai Yuhan, Liu Huiyu, Yan Xingyu, Li Xiaohui, Zhang Cong

Abstract excerpt

AIMS: Preeclampsia is a major cause of maternal and perinatal morbidity, yet the pathogenic role of clinical metabolic marker homocysteine (Hcy) remains poorly defined. This study aimed to verify whether gestational Hcy exposure triggers preeclampsia-like phenotypes, clarify underlying decidualization-related mechanisms, and investigate the rescue effect of folate supplementation. MATERIALS AND METHODS: We...

Topics

Female
Animals
Pregnancy
Pre-Eclampsia
Homocysteine
Mice
Phenotype
Neurodevelopment
Decidua
Folic Acid
Placenta
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Developmental

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Identifiers

PMID: 42409260
DOI: 10.1016/j.lfs.2026.124574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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