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Article

Aspirin has a better effect on PIK3CA mutant colorectal cancer cells by PI3K/Akt/Raptor pathway.

Molecular medicine (Cambridge, Mass.) - 30 Jan 2020

Chen Zhihang, Wang Chun, Dong Hao, Wang Xing, Gao Feng, Zhang Sen, Zhang Xiaolong

Abstract excerpt

BACKGROUND: Aspirin, as a non-steroidal anti-inflammatory drug, can improve the survival rate of patients with colorectal cancer, while aspirin is effective in patients with PIK3CA mutant colorectal cancer (CRC). However, the mechanism of aspirin in the treatment of PIK3CA mutated CRC patients remains unclear. METHODS: In this study, immunohistochemistry was used to detect the expression levels of PI3K and Raptor...

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Identifiers

PMID: 32000660
DOI: 10.1186/s10020-020-0139-5
PMCID: PMC6993447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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