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Article

A putative role for the aryl hydrocarbon receptor (AHR) gene in a patient with cyclical Cushing's disease.

BMC endocrine disorders - 29 Jan 2020

De Sousa Sunita M C, Manavis Jim, Feng Jinghua, Wang Paul, Schreiber Andreas W, Scott Hamish S, Torpy David J

Abstract excerpt

BACKGROUND: Apart from PRKAR1A mutations in a subset of cyclical Cushing's syndrome due to primary pigmented nodular adrenocortical disease, the molecular basis of cyclical Cushing's syndrome has not been investigated. We speculated that cyclical Cushing's syndrome may be due to mutations in the clock genes that govern circadian rhythms, including the hypothalamic-pituitary-adrenal axis. CASE PRESENTATION: A...

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Identifiers

PMID: 31996203
DOI: 10.1186/s12902-020-0495-8
PMCID: PMC6988286

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