Article
Increased frequency of the rs2066853 variant of aryl hydrocarbon receptor gene in patients with acromegaly.
Clinical endocrinology - 1 Aug 2014
Cannavo S, Ferrau F, Ragonese M, Romeo P D, Torre M L, Puglisi S, De Menis E, Arnaldi G, Salpietro C, Cotta O R, Albani A, Ruggeri R M, Trimarchi F
Abstract excerpt
CONTEXT: Aryl hydrocarbon receptor (AHR) pathway has a key role in cellular detoxification mechanisms and seems implicated in tumorigenesis. Moreover, polymorphisms and mutations of AHR gene have been associated with several human and animal tumours. Although AHR has been found differently expressed in pituitary adenomas, AHR gene mutation status has never been investigated in acromegalic patients. DESIGN: In...
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