Article
NGF (-198C > T, Ala35Val) and p75NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon.
Molecular medicine (Cambridge, Mass.) - 29 Jan 2020
Pereira Leonn Mendes Soares, da Silva Graça Amoras Ednelza, da Silva Conde Simone Regina Souza, Demachki Sâmia, Dos Santos Eduardo José Melo, Lima Sandra Souza, Ishak Ricardo, Rosário Vallinoto Antonio Carlos
Abstract excerpt
BACKGROUNDS: Neural growth factor (NGF) is a neurotrophin that can interact with the p75NTR receptor and initiate a cascade of reactions that determines cell survival or death, and both are associated with the physiology of liver tissue. Single nucleotide polymorphisms (SNPs) in the NGF and p75NTR genes have been investigated in different pathologies; however, there are no studies that have analyzed their...
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