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Article

Transcriptional profiling and genotyping of degraded nucleic acids from autopsy tissue samples after prolonged formalin fixation times.

International journal of clinical and experimental pathology - 6 Jan 2011

Ferruelo Antonio, El-Assar Mariam, Lorente José A, Nin Nicolás, Peñuelas Oscar, Fernández-Segoviano Pilar, Gonzalez Constancio, Esteban Andrés

Abstract excerpt

BACKGROUND: Samples used for genotyping and transcription studies are obtained and conserved in very specific conditions. The possibility to use autopsy tissue samples, which contain nucleic acids of very poor quality, would open new possibilities for genetic studies. METHODS: We have used liver tissue samples from autopsy cases to (i) determine its quality; (ii) study gene expression of 13 genes involved in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 21326810
PMCID: PMC3037201

Genes

ACE
TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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