Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Klotho Gene in Human Salt-Sensitive Hypertension.

Clinical journal of the American Society of Nephrology : CJASN - 6 Mar 2020

Citterio Lorena, Delli Carpini Simona, Lupoli Sara, Brioni Elena, Simonini Marco, Fontana Simone, Zagato Laura, Messaggio Elisabetta, Barlassina Cristina, Cusi Daniele, Manunta Paolo, Lanzani Chiara

Abstract excerpt

BACKGROUND AND OBJECTIVES: Hypertension is a common aging-related disorder. Salt intake is one of the main environmental factors contributing to the development of hypertension. Transgenic mice with one-half Klotho deficiency displayed a spontaneous BP increase and salt-sensitive hypertension in response to high sodium intake. Usually circulating levels of α-Klotho decrease with age, and this reduction may be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerular Filtration Rate

Share to Glucuronidase

Share to Hypertension

Share to Infusions, Intravenous

Share to Kidney

Share to Klotho Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 31992575
DOI: 10.2215/CJN.08620719
PMCID: PMC7057312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Klotho Gene in Human Salt-Sensitive Hypertension.PMID 31992575Read ↗

Molecular Basis of Klotho: From Gene to Function in AgingSemantic proximity Read ↗

Role of Klotho in the Development of Essential Hypertension.Semantic proximity Read ↗

Genomics and Pharmacogenomics of Salt-sensitive Hypertension.Semantic proximity Read ↗

Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice.Semantic proximity Read ↗

Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes.Semantic proximity Read ↗

Effects of environmental and genetic risk factors for salt sensitivity on blood pressure in northern China: the systemic epidemiology of salt sensitivity (EpiSS) cohort studySemantic proximity Read ↗

Genetics of salt-sensitive hypertension.Semantic proximity Read ↗

Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.Semantic proximity Read ↗

Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults.Semantic proximity Read ↗

Salt Sensitivity: Challenging and Controversial Phenotype of Primary Hypertension.Semantic proximity Read ↗

A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentrationSemantic proximity Read ↗

Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.