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Article

Interferon lambda 1 is associated with dengue severity in Thailand.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2020

Arayasongsak Unchana, Naka Izumi, Ohashi Jun, Patarapotikul Jintana, Nuchnoi Pornlada, Kalambaheti Thareerat, Sa-Ngasang Areerat, Chanama Sumalee, Chaorattanakawee Suwanna

Abstract excerpt

OBJECTIVES: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS). This study was performed to determine the host genetic factors responsible for dengue severity. Two single nucleotide polymorphisms (SNPs) of the interferon lambda 1 (IFNL1) gene (rs30461 and rs7247086) were...

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PMID: 31981768
DOI: 10.1016/j.ijid.2020.01.026

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