Article
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders.
PLoS genetics - 1 Jan 2020
Andersen Mette K, Jørsboe Emil, Skotte Line, Hanghøj Kristian, Sandholt Camilla H, Moltke Ida, Grarup Niels, Kern Timo, Mahendran Yuvaraj, Søborg Bolette, Bjerregaard Peter, Larsen Christina V L, Dahl-Petersen Inger K, Tiwari Hemant K, Feenstra Bjarke, Koch Anders, Wiener Howard W, Hopkins Scarlett E, Pedersen Oluf, Melbye Mads, Boyer Bert B, Jørgensen Marit E, Albrechtsen Anders, Hansen Torben
Abstract excerpt
The genetic architecture of the small and isolated Greenlandic population is advantageous for identification of novel genetic variants associated with cardio-metabolic traits. We aimed to identify genetic loci associated with body mass index (BMI), to expand the knowledge of the genetic and biological mechanisms underlying obesity. Stage 1 BMI-association analyses were performed in 4,626 Greenlanders. Stage 2...
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