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Article

KISS1/KISS1R and Breast Cancer: Metastasis Promoter

1 Jul 2019

Abstract excerpt

Abstract Kisspeptins (KPs), peptide products of the kisspeptin-1 (KISS1) gene, are the endogenous ligands for the KISS1 receptor, KISS1R, which is a G protein-coupled receptor. In many human tumors, KISS1 functions as a metastasis-suppressor gene and KISS1/KISS1R signaling has antimetastatic and tumor-suppressor roles. On the contrary, emerging evidence indicates that the KP/KISS1R pathway plays detrimental roles...

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PMID: 31972865
DOI: 10.1055/s-0039-3400968

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