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Deciphering protein–DNA interactions of KISS1 with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis

5 Sept 2025

Abstract excerpt

Metastasis is a key hallmark of cancer aggressiveness, particularly in triple-negative breast cancer (TNBC), which lacks effective targeted therapies. Kisspeptin-1 (KISS1), a known metastasis suppressor is emerging as a potential therapeutic modulator. This study investigates the structural and regulatory interactions between KISS1 and key transcription factors (TFs) involved in metastasis: SP1, CDX2, FLI1,...

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PMID: 40910466
DOI: 10.1080/07391102.2025.2553344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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