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Article

Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010

Aoyagi Mariko, Gaspar Miguel, Shenk Thomas E

Abstract excerpt

4EBP1 is phosphorylated by the mTORC1 kinase. When mTORC1 activity is inhibited, hypophosphorylated 4EBP1 binds and sequesters eIF4E, a component of the mRNA cap-binding complex, and blocks translation. As a consequence, mTORC1 activity is needed to maintain active translation. The human cytomegalovirus pUL38 protein preserves mTORC1 activity, keeping most of the E4BP1 in the infected cell in a...

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Identifiers

PMID: 20133758
DOI: 10.1073/pnas.0914856107
PMCID: PMC2823912

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