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Development and optimization of OspC chimeritope vaccinogens for Lyme disease

17 Jan 2020

Abstract excerpt

Experimental Outer surface protein (Osp) C based subunit chimeritope vaccinogens for Lyme disease (LD) were assessed for immunogenicity, structure, ability to elicit antibody (Ab) responses to divergent OspC proteins, and bactericidal activity. Chimeritopes are chimeric epitope based proteins that consist of linear epitopes derived from multiple proteins or multiple variants of a protein. An inherent advantage to...

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PMID: 31959423
DOI: 10.1016/j.vaccine.2020.01.027

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