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BB0323 and Novel Virulence Determinant BB0238:Borrelia burgdorferiProteins That Interact With and Stabilize Each Other and Are Critical for Infectivity

19 Aug 2014

Abstract excerpt

We have shown that Borrelia burgdorferi gene product BB0323 is essential for cell fission and pathogen persistence in vivo. Here we describe characterization of a conserved hypothetical protein annotated as BB0238, which specifically interacts with the N-terminal region of BB0323. We show that BB0238 is a subsurface protein, and similar to BB0323, exists in the periplasm and as a membrane-bound protein. Deletion...

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PMID: 25139020
DOI: 10.1093/infdis/jiu460

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