Article
MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3).
The Journal of biological chemistry - 5 Sept 2014
Yang Chuan He, Yue Junming, Pfeffer Susan R, Fan Meiyun, Paulus Elena, Hosni-Ahmed Amira, Sims Michelle, Qayyum Sohail, Davidoff Andrew M, Handorf Charles R, Pfeffer Lawrence M
Abstract excerpt
Despite advances in surgery, imaging, chemotherapy, and radiation, patients with glioblastoma multiforme (GBM), the most common histological subtype of glioma, have an especially dismal prognosis; >70% of GBM patients die within 2 years of diagnosis. In many human cancers, the microRNA miR-21 is overexpressed, and accumulating evidence indicates that it functions as an oncogene. Here, we report that miR-21 is...
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