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Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

17 Jan 2020

Abstract excerpt

DNA double strand breaks (DSBs) have detrimental effects on cell survival and genomic stability, and are related to cancer and other human diseases. In this study, we identified microtubule-depolymerizing kinesin Kif2C as a protein associated with DSB-mimicking DNA templates and known DSB repair proteins in Xenopus egg extracts and mammalian cells. The recruitment of Kif2C to DNA damage sites was dependent on...

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PMID: 31951198
DOI: 10.7554/elife.53402

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