Article
Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer.
Cells - 14 Jan 2020
Marín-Aguilera Mercedes, Jiménez Natalia, Reig Òscar, Montalbo Ruth, Verma Ajit K, Castellano Giancarlo, Mengual Lourdes, Victoria Iván, Pereira María V, Milà-Guasch Maria, García-Recio Susana, Benítez-Ribas Daniel, Cabezón Raquel, González Azucena, Juan Manel, Prat Aleix, Mellado Begoña
Abstract excerpt
Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether the expression of AR full-length (ARFL) and its splicing variant ARV7 in peripheral blood mononuclear cells (PBMC) predicts systemic treatment response in mCRPC in comparison with circulating-tumor cells (CTC). We measured ARFL and ARV7 mRNA in PBMC and...
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