Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A microbiota-derived metabolite, 3-phenyllactic acid, prolongs healthspan by enhancing mitochondrial function and stress resilience via SKN-1/ATFS-1 in C. elegans

30 Dec 2024

Abstract excerpt

The mechanisms underlying the impact of probiotic supplementation on health remain largely elusive. While previous studies primarily focus on the discovery of novel bioactive bacteria and alterations in the microbiome environment to explain potential probiotic effects, our research delves into the role of living Lactiplantibacillus (formerly known as Lactobacillus) and their conditioned media, highlighting that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Gut microbiota and health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39737960
DOI: 10.1038/s41467-024-55015-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A microbiota-derived metabolite, 3-phenyllactic acid, prolongs healthspan by enhancing mitochondrial function and stress resilience via SKN-1/ATFS-1 in C. elegansPMID 39737960Read ↗

3-phenyllactic acid promotes healthspan through SKN-1/ATFS-1-mediated mitochondrial activation and stress resilienceSemantic proximity Read ↗

Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegansSemantic proximity Read ↗

Longevity-promoting human gut <i>Bifidobacteria</i> strains require distinct cytoprotective pathways and share dependence on host lipid regulationSemantic proximity Read ↗

Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegansSemantic proximity Read ↗

Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16Semantic proximity Read ↗

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1Semantic proximity Read ↗

Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct MechanismsSemantic proximity Read ↗

Microbial dysbiosis and the aging process: a review on the potential age-deceleration role of Lactiplantibacillus plantarumSemantic proximity Read ↗

Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegansSemantic proximity Read ↗

Heat-killed probiotic <i>Levilactobacillus brevis</i> MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

IMPACT OF PHENOLIC ACIDS ON THE ENERGY METABOLISM AND LONGEVITY IN <i>C. ELEGANS</i>Semantic proximity Read ↗

Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.