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Article

Attenuation of Wnt/β-catenin signaling in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.

International journal of biological sciences - 1 Jan 2020

Chen Chun-Bing, Chang Wan-Chun, Wu Ming-Ying, Kao Tzu-Yang, Wang Ying-Wen, Wang Chuang Wei, Chen Chi-Ju, Chung Wen-Hung, Su Shih-Chi

Abstract excerpt

Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Current studies have suggested that the pathobiology of drug-mediated SJS/TEN involves a dysregulation of cellular immunity with overwhelming activation of cytotoxic T lymphocytes. The canonical Wnt signaling pathway plays important roles in T cell development and activation, which...

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Identifiers

PMID: 31929762
DOI: 10.7150/ijbs.32331
PMCID: PMC6949146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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