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Article

Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression

13 Jan 2020

Abstract excerpt

BACKGROUND: Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related oncoprogression for GC. METHODS: From August to December 2013, 106 GC patients were prospectively included. The regional expression of C3 and other...

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PMID: 31928530
DOI: 10.1186/s13046-019-1514-3

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