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Future Perspectives and Conclusions from Animal Models of CHI3L1-Related Inflammation-Associated Cancer

26 Jun 2025

Abstract excerpt

Among the molecules implicated in inflammation-associated tumorigenesis, Chitinase 3-like 1 (CHI3L1/YKL-40/Brp-39) has emerged as a particularly compelling target due to its multifaced roles in immune regulation, tissue remodeling, and cancer progression. Elevated CHI3L1 expression is observed in various human cancers and corresponding animal models. CHI3L1 directly promotes tumor cell proliferation and...

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PMID: 40643503
DOI: 10.3390/cells14130982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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