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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

16 Dec 2019

Abstract excerpt

NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors (BaEV-LVs) encoding eGFP, we obtained a transduction rate of 23.0±6.6% (mean±SD) in freshly-isolated human NK-cells (FI-NK) and 83.4±10.1% (mean±SD) in NK-cells obtained from the NK-cell Activation and Expansion System (NKAES), with a sustained transgene...

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PMID: 31921138
DOI: 10.3389/fimmu.2019.02873

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