Article
A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020
Ahmetaj-Shala Blerina, Kawai Ryota, Marei Isra, Nikolakopoulou Zacharoula, Shih Chih-Chin, Konain Bhatti, Reed Daniel M, Mongey Róisín, Kirkby Nicholas S, Mitchell Jane A
Abstract excerpt
Blood vessels are comprised of endothelial and smooth muscle cells. Obtaining both types of cells from vessels of living donors is not possible without invasive surgery. To address this, we have devised a strategy whereby human endothelial and smooth muscle cells derived from blood progenitors from the same donor could be cultured with autologous leukocytes to generate a same donor "vessel in a dish" bioassay....
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