Cell-based methods for ex vivo evaluation of human endothelial biology.

Abstract excerpt

The endothelium plays a central role in cardiovascular regulation. Endothelial cells produce a variety of vasculoregulatory and vasculotropic molecules that act locally or at distant sites. Alteration of the vascular endothelium is a primary event in the pathogenesis of vascular diseases, such as atherosclerosis, as well as systemic and pulmonary hypertension. For these reasons, the study of human endothelium has...

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