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Article

Detailed Characteristics of Tonsillar Tumors with Extrachromosomal or Integrated Form of Human Papillomavirus.

Viruses - 30 Dec 2019

Pokrývková Barbora, Saláková Martina, Šmahelová Jana, Vojtěchová Zuzana, Novosadová Vendula, Tachezy Ruth

Abstract excerpt

The human papillomavirus (HPV) integration, the critical step in viral carcinogenesis, most frequently occurs in the E2 gene, which results in its inactivation and in an increase of E6/E7 transcription. However, in a substantial number of tumors, the virus is present in an extrachromosomal form. For those tumors, the transformation mechanisms are not fully elucidated. Here we evaluated the possible mechanism of...

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Identifiers

PMID: 31905862
DOI: 10.3390/v12010042
PMCID: PMC7019694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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