Article
Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2020
de Kock Leanne, Yoon Ju-Yoon, Apellaniz-Ruiz Maria, Pelletier Dylan, McCluggage W Glenn, Stewart Colin J R, Dickson Brendan C, Rouzbahman Marjan, Clarke Blaise A, Foulkes William D
Abstract excerpt
Embryonal rhabdomyosarcomas (ERMS) account for 2-3% of cancers in pediatric and adolescent populations. They are rarer in adults. We and others have reported that ERMS arising in the uterine cervix may harbor mutations in the gene encoding the microRNA biogenesis enzyme, DICER1, but a large series of cases has not been published. In the uterus, distinguishing ERMS from adenosarcoma can be very challenging, even...
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