Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.

doi:10.1038/s41379-021-00804-y

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Article

Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2021

Kommoss Felix K F, Stichel Damian, Mora Jaume, Esteller Manel, Jones David T W, Pfister Stefan M, Brack Eva, Wachtel Marco, Bode Peter Karl, Sinn Hans-Peter, Schmidt Dietmar, Mentzel Thomas, Kommoss Friedrich, Sahm Felix, von Deimling Andreas, Koelsche Christian

Abstract excerpt

Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently harbor DICER1 mutations. Interestingly, only rare cases of extrauterine DICER1-associated ERMS, mostly located in the genitourinary tract, have been reported to date. Our goal was to study clinicopathologic and molecular profiles of DICER1-mutant (DICER1-mut) and DICER1-wild type (DICER1-wt) ERMS in a cohort of genitourinary...

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PMID: 33846547
DOI: 10.1038/s41379-021-00804-y
PMCID: PMC8295035

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