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Article

The mesenchymal stem cells derived from transgenic mice carrying human coagulation factor VIII can correct phenotype in hemophilia A mice.

Journal of genetics and genomics = Yi chuan xue bao - 20 Dec 2013

Wang Qing, Gong Xiuli, Gong Zhijuan, Ren Xiaoyie, Ren Zhaorui, Huang Shuzhen, Zeng Yitao

Abstract excerpt

Hemophilia A (HA) is an inherited X-linked recessive bleeding disorder caused by coagulant factor VIII (FVIII) deficiency. Previous studies showed that introduction of mesenchymal stem cells (MSCs) modified by FVIII-expressing retrovirus may result in phenotypic correction of HA animals. This study aimed at the investigation of an alternative gene therapy strategy that may lead to sustained FVIII transgene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24377868
DOI: 10.1016/j.jgg.2013.11.002

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