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Article

Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility.

The Journal of biological chemistry - 14 Feb 2020

Chrissian Christine, Camacho Emma, Fu Man Shun, Prados-Rosales Rafael, Chatterjee Subhasish, Cordero Radames J B, Lodge Jennifer K, Casadevall Arturo, Stark Ruth E

Abstract excerpt

Cryptococcus neoformans and Cryptococcus gattii are two species complexes in the large fungal genus Cryptococcus and are responsible for potentially lethal disseminated infections. These two complexes share several phenotypic traits, such as production of the protective compound melanin. In C. neoformans, the pigment associates with key cellular constituents that are essential for melanin deposition within the...

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Identifiers

PMID: 31896575
DOI: 10.1074/jbc.RA119.011949
PMCID: PMC7029119

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