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Article

Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

PloS one - 1 Jan 2019

Watanabe Fumiaki, Suzuki Koichi, Tamaki Sawako, Abe Iku, Endo Yuhei, Takayama Yuji, Ishikawa Hideki, Kakizawa Nao, Saito Masaaki, Futsuhara Kazushige, Noda Hiroshi, Konishi Fumio, Rikiyama Toshiki

Abstract excerpt

BACKGROUND: Liquid biopsies enable the detection of circulating tumor DNA (ctDNA). However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential. METHODS AND FINDINGS: A total of 422 blood samples were collected from 78 patients undergoing treatments for localized and metastatic pancreatic ductal adenocarcinoma. KRAS...

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Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circulating Tumor DNA

Share to Longitudinal Studies

Share to Neoplasm Recurrence, Local

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 31891652
DOI: 10.1371/journal.pone.0227366
PMCID: PMC6938323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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