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Article

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans

27 Dec 2019

Abstract excerpt

Abstract [Pyr 1 ]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr 1 ]apelin-13 metabolism in vivo in rats with no studies examining its stability in humans. We therefore aimed to develop an LC-MS/MS method for detection and quantification of intact [Pyr 1 ]apelin-13 and have used this method to identify the metabolites...

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Identifiers

PMID: 31882594
DOI: 10.1038/s41598-019-56157-9

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