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Article

Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in Cryptococcus neoformans.

Genetics - 1 Mar 2020

Ianiri Giuseppe, Fang Yufeng Francis, Dahlmann Tim A, Clancey Shelly Applen, Janbon Guilhem, Kück Ulrich, Heitman Joseph

Abstract excerpt

The MAT locus of Cryptococcus neoformans has a bipolar organization characterized by an unusually large structure, spanning over 100 kb. MAT genes have been characterized by functional genetics as being involved in sexual reproduction and virulence. However, classical gene replacement failed to achieve mutants for five MAT genes (RPL22, RPO41, MYO2, PRT1, and RPL39), indicating that they are likely essential. In...

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Identifiers

PMID: 31882399
DOI: 10.1534/genetics.119.302740
PMCID: PMC7054023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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