Article
SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly.
Cellular microbiology - 1 May 2020
Bitew Mebratu A, Hofmann Janine, De Souza David P, Wawegama Nadeeka K, Newton Hayley J, Sansom Fiona M
Abstract excerpt
Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrophages within a highly oxidative vacuole. Screening of a transposon mutant library suggested that sdrA, which encodes a putative short-chain dehydrogenase, is required for intracellular replication. Short-chain dehydrogenases are NADP(H)-dependent oxidoreductases, and SdrA contains a...
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