Article
Monitoring treatment efficacy and resistance in breast cancer patients via circulating tumor DNA genomic profiling.
Molecular genetics & genomic medicine - 1 Feb 2020
Chen Zhanhong, Sun Tian, Yang Ziyan, Zheng Yabing, Yu Ruoying, Wu Xue, Yan Junrong, Shao Yang W, Shao Xiying, Cao Wenming, Wang Xiaojia
Abstract excerpt
BACKGROUND: One of the major challenges in managing invasive breast cancer (BC) is the lack of reliable biomarkers to track response. Circulating tumor DNA (ctDNA) from liquid biopsy, as a candidate biomarker, provides a valuable assessment of BC patients. In this retrospective study, we evaluated the utility of ctDNA to reflect the efficacy of treatment and to monitor resistance mechanisms. METHODS: Targeted...
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