Article
Early evaluation of circulating tumor DNA as marker of therapeutic efficacy and prognosis in breast cancer patients during primary systemic therapy.
Breast (Edinburgh, Scotland) - 1 Aug 2024
Wang Ru, Wang Bin, Zhang Huimin, Liao Xiaoqin, Shi Bohui, Zhou Yuhui, Zhou Can, Yan Yu, Zhang Wei, Wang Ke, Ge Guanqun, Ren Yu, Tang Xiaojiang, Gan Baoyu, He Jianjun, Niu Ligang
Abstract excerpt
BACKGROUND: We assessed the potential role of serial circulating tumor DNA (ctDNA) as a biomarker to monitor treatment response to primary systemic therapy (PST) in breast cancer and evaluated the predictive value of ctDNA to further identify patients with residual disease. METHODS: We prospectively enrolled 208 plasma samples collected at three time points (before PST, after 2 cycles of treatment, before...
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