Article
Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers.
Molecular carcinogenesis - 1 Oct 2016
Weng Daniel Y, Chen Jinguo, Taslim Cenny, Hsu Ping-Ching, Marian Catalin, David Sean P, Loffredo Christopher A, Shields Peter G
Abstract excerpt
The number of validated biomarkers of tobacco smoke exposure is limited, and none exist for tobacco-related cancer. Additional biomarkers for smoke, effects on cellular systems in vivo are needed to improve early detection of lung cancer, and to assist the Food and Drug Administration in regulating exposures to tobacco products. We assessed the effects of smoking on the gene expression using human cell cultures...
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