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Article

Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling.

BMC cancer - 19 Dec 2019

Lone Mehraj-U-Din, Miyan Javed, Asif Mohammad, Malik Showkat A, Dubey Parul, Singh Varsha, Singh Kavita, Mitra Kalyan, Pandey Deepali, Haq Wahajul, Amita Himanshi, Singh Prince Kumar, Kiess Wieland, Kaessner Franziska, Garten Antje, Bhadauria Smrati

Abstract excerpt

BACKGROUND: The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellular functions in response to growth factors, cellular energy levels, and nutrients. The mechanisms regulating mTORC1 activity are well characterized; regulation of mTORC2 activity, however,...

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Identifiers

PMID: 31856761
DOI: 10.1186/s12885-019-6422-6
PMCID: PMC6921532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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