Article
Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2020
Pairawan Seyed, Hess Kenneth R, Janku Filip, Sanchez Nora S, Mills Shaw Kenna R, Eng Cathy, Damodaran Senthilkumar, Javle Milind, Kaseb Ahmed O, Hong David S, Subbiah Vivek, Fu Siqing, Fogelman David R, Raymond Victoria M, Lanman Richard B, Meric-Bernstam Funda
Abstract excerpt
PURPOSE: Physicians are expected to assess prognosis both for patient counseling and for determining suitability for clinical trials. Increasingly, cell-free circulating tumor DNA (cfDNA) sequencing is being performed for clinical decision making. We sought to determine whether variant allele frequency (VAF) in cfDNA is associated with prognosis. EXPERIMENTAL DESIGN: We performed a retrospective analysis of 298...
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