Article
Next-Generation Sequencing Identifies BRCA1 and/or BRCA2 Mutations in Women at High Hereditary Risk for Breast Cancer with Shorter Telomere Length.
Omics : a journal of integrative biology - 1 Jan 2020
Peker Eyüboğlu İrem, Yenmiş Güven, Bingöl Elif Naz, Yüksel Şirin, Tokat Fatma, Özbek Pemra, Güllü Amuran Gökçe, Yakıcıer Cengiz, Akkiprik Mustafa
Abstract excerpt
Telomeres, and telomere length in particular, have broad significance for genome biology and thus are prime research targets for complex diseases such as cancers. In this context, BRCA1 and BRCA2 gene mutations have been implicated in relationship to telomere length, and breast cancer susceptibility. Yet, the linkages among human genetic variation and telomere length in persons with high hereditary cancer risk...
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